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Penile Cancer: Overview

What is penile cancer?

Cancer is made of changed cells that grow out of control. The changed (abnormal) cells often grow to form a lump or mass called a tumor. Cancer cells can also grow into (invade) nearby areas. And they can spread to other parts of the body. This is called metastasis.

Cancer that starts in cells in the penis is called penile cancer. Most penile cancer is squamous cell carcinoma. This means the cancer begins in the flat skin cells (squamous cells) of the penis. Most penile cancers begin on the foreskin or on the tip of the penis (glans). Penile cancer typically grows slowly. It can often be cured if it is found early.

Who is at risk for penile cancer?

A risk factor is anything that may increase your chance of having a disease. The exact cause of someone’s cancer may not be known. But risk factors can make it more likely for a person to have cancer. Some risk factors may not be in your control. But others may be things you can change. 

The risk factors for penile cancer include:

  • Being in your 50s or older

  • Not being circumcised

  • Having a foreskin that is hard to retract (phimosis) or a buildup of oil and dead skin cells under the foreskin (smegma)

  • HPV (human papilloma virus) infection

  • Smoking

  • Having AIDS

  • Having ultraviolet light treatment (PUVA) for psoriasis, a skin disease

Talk with your healthcare provider about your risk factors for penile cancer and what you can do about them.

Can penile cancer be prevented?

There is no sure way to prevent penile cancer. But you may be able to lower your risk for penile cancer by making some lifestyle changes. These include:

  • Not smoking

  • Having safer sex

  • Having good personal hygiene habits, especially if you are not circumcised

What are the symptoms of penile cancer?

The symptoms of penile cancer can vary from person to person. The most common symptoms include:

  • An ulcer, sore, or growth on the penis, especially on the glans or foreskin.

  • Changes in skin color, skin thickening, or tissue growth

  • A red, velvet-like rash

  • Bleeding from a growth or sore

  • Small and crusty bumps

  • Flat growths with a bluish brown color

  • A discharge under the foreskin, with or without an odor

  • Swelling at the tip of the penis, especially if the foreskin is tight

  • Swelling in the groin area, which may be caused by an enlarged lymph node

Many of these symptoms can be caused by other health problems. But it is important to see a healthcare provider if you have these symptoms. Only a healthcare provider can tell if you have cancer.

How is penile cancer diagnosed?

Your healthcare provider will ask you about your health history, your symptoms, risk factors, and family history of disease. He or she will also give you a physical exam. Penile cancer usually starts on the surface of the penis. So your healthcare provider can see and feel it.

A biopsy is the only way to confirm if you have penile cancer. Part or all of the abnormal area will be removed during a surgical procedure. The area may be numbed first with a local anesthetic. The biopsy samples are sent to a lab and checked for cancer cells. Your results will come back in about 1 week.

After a diagnosis of penile cancer, you may have other tests. These help your healthcare providers learn more about the cancer. They can help determine the stage of the cancer. The stage is how much and how far the cancer has spread (metastasized) in your body. It is one of the most important things to know when deciding how to treat the cancer.

Once your cancer is staged, your healthcare provider will talk with you about what the stage means for your treatment. Be sure to ask your healthcare provider to explain the stage of your cancer to you in a way you can understand.

How is penile cancer treated?

Your treatment choices depend on the size, location, and stage of the cancer. Other things to think about are if the cancer can be removed with surgery, and your overall health. The goal of treatment may be to cure you, control the cancer, or help ease problems caused by the cancer. Talk with your healthcare team about your treatment choices, the goals of treatment, and what the risks and side effects may be.

Types of treatment for cancer are either local or systemic. Local treatments remove, destroy, or control cancer cells in one area. Surgery and radiation are local treatments. Systemic treatment is used to destroy or control cancer cells that may have traveled around your body. When taken by pill or injection, chemotherapy is a systemic treatment. 

You may have just one treatment or a combination of treatments.

Talk with your healthcare provider about your treatment options. Make a list of questions. Think about the benefits and possible side effects of each option. Talk about your concerns with your healthcare provider before making a decision.

What are treatment side effects?

Cancer treatments such as chemotherapy and radiation can damage normal cells. This causes side effects such as hair loss, mouth sores, and vomiting. Talk with your healthcare provider about the side effects you might have and ways to manage them. There may be things you can do and medicines you can take to help prevent or control side effects.

Coping with penile cancer

Many people feel worried, depressed, and stressed when dealing with cancer. Getting treatment for cancer can be hard on your mind and body. Keep talking with your healthcare team about any problems or concerns you have. Work together to ease the effects of cancer and its symptoms on your daily life.

Here are tips:

  • Talk with your family or friends.

  • Ask your healthcare team or social worker for help.

  • Speak with a counselor.

  • Talk with a spiritual advisor, such as a minister or rabbi.

  • Ask your healthcare team about medicines for depression or anxiety.

  • Keep socially active.

  • Join a cancer support group.

Cancer treatment is also hard on the body. To help yourself stay healthier, try to:

  • Eat a healthy diet, with a focus on high-protein foods.

  • Drink plenty of water, fruit juices, and other liquids.

  • Keep physically active.

  • Rest as much as needed.

  • Talk with your healthcare team about ways to manage treatment side effects.

  • Take your medicines as directed by your team.

When should I call my healthcare provider?

Your healthcare provider will talk with you about when to call. You may be told to call if you have:

  • New symptoms or symptoms that get worse

  • Signs of an infection, such as a fever

  • Side effects of treatment that affect your daily function or don’t get better with treatment

Ask your healthcare provider what signs to watch for, and when to call. Know how to get help after office hours and on weekends and holidays.

Key points about penile cancer

Next steps

Tips to help you get the most from a visit to your healthcare provider:

  • Know the reason for your visit and what you want to happen.

  • Before your visit, write down questions you want answered.

  • Bring someone with you to help you ask questions and remember what your provider tells you.

  • At the visit, write down the name of a new diagnosis, and any new medicines, treatments, or tests. Also write down any new instructions your provider gives you.

  • Know why a new medicine or treatment is prescribed, and how it will help you. Also know what the side effects are.

  • Ask if your condition can be treated in other ways.

  • Know why a test or procedure is recommended and what the results could mean.

  • Know what to expect if you do not take the medicine or have the test or procedure.

  • If you have a follow-up appointment, write down the date, time, and purpose for that visit.

  • Know how you can contact your provider if you have questions.

Online Medical Reviewer: Louise Cunningham, RN
Online Medical Reviewer: Rick Alteri, MD
Date Last Reviewed: 10/1/2017
© 2019 The StayWell Company, LLC. 800 Township Line Road, Yardley, PA 19067. All rights reserved. This information is not intended as a substitute for professional medical care. Always follow your healthcare provider's instructions.