FLUOXETINE; OLANZAPINE (floo OX e teen; oh LAN za peen) is used to treat episodes of depression that have not been relieved by the use of other medicines and depression caused by bipolar disorder.
Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. You can take this medicine with or without food. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not stop taking this medicine suddenly except upon the advice of your doctor. Stopping this medicine too quickly may cause serious side effects or your condition may worsen.
A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.
Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 10 years of age for selected conditions, precautions do apply.
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
changes in vision
difficulty in speaking or swallowing
elevated mood, decreased need for sleep, racing thoughts, impulsive behavior
fever or chills, sore throat
fever with rash, swollen lymph nodes, or swelling of the face
muscle spasms or weakness
painful or prolonged erections
redness, blistering, peeling or loosening of the skin, including inside the mouth
restlessness, pacing, inability to keep still
signs and symptoms of high blood sugar such as being more thirsty or hungry or having to urinate more than normal. You may also feel very tired or have blurry vision.
suicidal thoughts or other mood changes
unusual bleeding or bruising
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
change in sex drive or performance
Do not take this medicine with any of the following medications:
other medicines containing fluoxetine or olanzapine, such as Prozac, Sarafem, or Zyprexa
MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
methylene blue (injected into a vein)
This medicine may also interact with the following medications:
aspirin or aspirin-like medicines
certain medicines for depression, anxiety, or psychotic disturbances
certain medicines for migraine headaches like almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan
medicines for high blood pressure
medicines for Parkinson's disease
medicines for sleep
medicines that treat or prevent blood clots like warfarin, enoxaparin, and dalteparin
NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
other medicines that prolong the QT interval (cause an abnormal heart rhythm)
supplements like St. John's wort, kava kava, valerian
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from moisture. Keep container tightly closed. Throw away any unused medicine after the expiration date.
They need to know if you have any of these conditions:
Alzheimer's disease or dementia
heart disease, irregular heartbeat, or previous heart attack
high blood pressure treated with medication
low blood pressure
low levels of potassium or magnesium in the blood
receiving electroconvulsive therapy
strokes, or mini-strokes called transient ischemic attacks (TIAs)
suicidal thoughts, plans, or attempt; a previous suicide attempt by you or a family member
an unusual or allergic reaction to fluoxetine, olanzapine, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
Tell your doctor if your symptoms do not get better or if they get worse. Visit your doctor or health care provider for regular checks on your progress. Because it may take several weeks to see the full effects of this medicine, it is important to continue your treatment as prescribed by your doctor.
Patients and their families should watch out for new or worsening thoughts of suicide or depression. Also watch out for sudden changes in feelings such as feeling anxious, agitated, panicky, irritable, hostile, aggressive, impulsive, severely restless, overly excited and hyperactive, or not being able to sleep. If this happens, especially at the beginning of treatment or after a change in dose, call your healthcare provider.
This medicine may increase blood sugar. Ask your healthcare provider if changes in diet or medicines are needed if you have diabetes.
You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.
Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.
This medicine can reduce the response of your body to heat or cold. Dress warm in cold weather and stay hydrated in hot weather. If possible, avoid extreme temperatures like saunas, hot tubs, very hot or cold showers, or activities that can cause dehydration such as vigorous exercise.