RETEPLASE (RE te plays) is used to dissolve blood clots that form in certain blood vessels. This medicine is used when a blood clot in a heart artery causes a heart attack.
This medicine is for injection into a vein. It is usually given by a health care professional in a hospital or clinic setting.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
signs and symptoms of bleeding such as bloody or black, tarry stools; red or dark-brown urine; spitting up blood or brown material that looks like coffee grounds; red spots on the skin; unusual bruising or bleeding from the eye, gums, or nose
signs and symptoms of a stroke such as changes in vision; confusion; trouble speaking or understanding; severe headaches; sudden numbness or weakness of the face, arm, or leg; trouble walking, dizziness, loss of balance or coordination
slow or fast heart rate
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
Do not take this medicine with any of the following medications:
This medicine may also interact with the following medications:
antiplatelet drugs such as ticlopidine or clopidogrel
aspirin and aspirin-like drugs
medicines that treat or prevent blood clots like warfarin, heparin, enoxaparin, and dalteparin
NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
This does not apply.
This drug is given in a hospital or clinic and will not be stored at home.
They need to know if you have any of these conditions:
bleeding problems or problems with blood clotting
diabetic retinopathy or bleeding problems of the eye
endocarditis (infection of the heart valves)
head injury, brain disease, or tumor
high blood pressure
recent biopsy, childbirth, surgery, or trauma (injury)
recent history of stroke
stomach ulcer or bleeding ulcer-an unusual or allergic reaction to reteplase, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
You will be closely monitored to check your progress after you receive this medicine. Follow the advice of your doctor or health care professional exactly. You may need bed rest to minimize the risk of bleeding.
This medicine can make you bleed more easily. This effect can last for several days. Try to avoid damage to your teeth and gums when you brush or floss your teeth, and try to avoid any other injury to yourself.
Do not take aspirin, ibuprofen, or other nonprescription pain relievers during or for several days after treatment with this medicine unless otherwise told to do so by your doctor or health care professional.