UROKINASE (yoor uh KAHY neys) breaks-up blood clots. It is used to treat large blood clots formed in the lungs.
This medicine is for injection into a vein. It is given by a health care professional in a hospital or clinic setting.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
blue color to lips or nailbeds
fast, irregular heartbeat
signs and symptoms of bleeding such as bloody or black, tarry stools; red or dark-brown urine; spitting up blood or brown material that looks like coffee grounds; red spots on the skin; unusual bruising or bleeding from the eye, gums, or nose
signs and symptoms of a stroke such as changes in vision; confusion; trouble speaking or understanding; severe headaches; sudden numbness or weakness of the face, arm or leg; trouble walking, dizziness, loss of balance or coordination
trouble passing urine or change in the amount of urine
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
Do not take this medicine with any of the following medications:
This medicine may also interact with the following medications:
antiinflammatory drugs, NSAIDs like ibuprofen
aspirin and aspirin-like medicines
fish oil (omega-3 fatty acids) supplements
medicines that treat or prevent blood clots like warfarin, enoxaparin, and dalteparin
This does not apply.
This drug is given in a hospital or clinic and will not be stored at home.
They need to know if you have any of these conditions:
bleeding problems or problems with blood clotting
blood vessel disease or damaged blood vessels
head injury or tumor
high blood pressure
recent biopsy or surgery
an unusual or allergic reaction to urokinase, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
Your condition will be monitored carefully while you are receiving this medicine.
This medicine contains albumin from human blood. It may be possible to pass an infection in this medicine. Talk to your doctor about the risks and benefits of this medicine.
This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.
Do not take aspirin, ibuprofen, or other nonprescription pain relievers for several days after receiving this medicine.