Orlistat (OR li stat) is used to help people lose weight and keep the weight off while eating a reduced-calorie diet. This medicine decreases the amount of fat that is absorbed from your diet.
Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take this medicine with each main meal that contains about 30 percent of the calories from fat or within 1 hour after each meal. Do not take your medicine more often than directed. If you occasionally miss a meal or have a meal without fat, you can skip that dose of this medicine.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed. While this drug may be prescribed for children as young as 12 years for selected conditions, precautions do apply. Use of this medicine without a prescription is not approved in children less than 18 years.
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
bloody or black, tarry stools
signs of infection like fever or chills
signs and symptoms of kidney stones like blood in the urine; pain in the lower back or side; pain when urinating
signs and symptoms of liver injury like dark yellow or brown urine; general ill feeling or flu-like symptoms; light-colored stools; loss of appetite; nausea; right upper belly pain; unusually weak or tired; yellowing of the eyes or skin
trouble passing urine or change in the amount of urine
uncontrolled, urgent bowel movements
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
increased number of bowel movements
oily stools (bowel movements may be clear, orange or brown in color)
stomach discomfort, gas
antiviral medicines for HIV or AIDS
certain medicines for hepatitis
certain medicines that treat or prevent blood clots like warfarin, enoxaparin, dalteparin, apixaban, dabigatran, edoxaban, and rivaroxaban
medicines for diabetes
medicines for seizures
other medicines or products for weight loss
supplements like vitamins A, D, E and K
If you miss a dose, take it within 1 hour following the meal that contains fat. If it is almost time for your next dose, take only that dose. Do not take double or extra doses. If you occasionally miss a meal or have a meal without fat, you can skip that dose of this medicine.
Keep out of the reach of children.
Storage at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep container tightly closed. Throw away any unused medicine after the expiration date.
They need to know if you have any of these conditions:
an eating disorder, such as anorexia or bulimia
HIV or AIDS
liver disease or hepatitis
problems absorbing food
stomach or intestine problems
take medicines that treat or prevent blood clots
an unusual or allergic reaction to orlistat, other medicines, foods, dyes, supplements or preservatives
pregnant or trying to get pregnant
Do not use this medicine if you have had an organ transplant. This medicine interferes with some of the medicines used to prevent transplant rejection.
This medicine can cause decreased absorption of some vitamins. You should take a daily multivitamin that contains normal amounts of vitamins D, E, K and beta-carotene or vitamin A. Take the multivitamin once per day at bedtime unless otherwise directed by your doctor or healthcare professional.
You should use this medicine with a reduced-calorie diet that contains no more than about 30 percent of the calories from fat. Divide your daily intake of fat, carbohydrates, and protein evenly over your 3 main meals. Follow a well-balanced, reduced-calorie, low fat diet. Try starting this diet before taking this medicine. Following a low fat diet can help reduce the possible side effects from this medicine.
Do not use this medicine if you are pregnant. Losing weight while pregnant is not advised and may cause harm to the unborn child. Talk to your health care professional or pharmacist for more information.