CISAPRIDE (SIS a pride) is used to treat heartburn in patients with gastroesophageal reflux disease (GERD). Because of the serious risks associated with this medicine it should only be used when lifestyle changes and other medicines have not worked. This medicine in only available from your doctor, who must register with the drug company and meet certain criteria for the use of this drug. Cisapride has not been available in pharmacies since August 2000. For information, the manufacturer has provided the following toll-free number (877) 795-4247.
Take this medicine by mouth with a glass of water. Follow the directions on the label. Take this medicine on an empty stomach, at least 15 minutes before eating and at bedtime. Do not take your medicine more often than directed.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Side effects that you should report to your doctor or health care professional as soon as possible:
fainting or falling spells
rapid or irregular heartbeat
unusually weak or tired
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
diarrhea or constipation
Do not take this medicine with any of the following medications:
antiviral medicines for HIV or AIDS
certain antibiotics like ciprofloxacin, clarithromycin, dalfopristin;quinupristin, erythromycin, gatifloxacin, gemifloxacin, levofloxacin, moxifloxacin, norfloxacin, ofloxacin, pentamidine, sparfloxacin, telithromycin, troleandomycin
certain medicines for cancer like daunorubicin, doxorubicin, imatinib
certain medicines for depression, anxiety, or other psychotic disturbances like clozapine, haloperidol, pimozide, risperidone, ziprasidone
certain medicines for erectile dysfunction like sildenafil, tadalafil, vardenafil
certain medicines for fungal infections like fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole
certain medicines for irregular heart beat like amiodarone, disopyramide, bretylium, dofetilide, dronedarone, flecainide, ibutilide, procainamide, propafenone, quinidine, sotalol
general and local anesthetics
other medicines that prolong the QT interval (cause an abnormal heart rhythm)
phenothiazines like chlorpromazine, fluphenazine, mesoridazine, perphenazine, prochlorperazine, promethazine, thioridazine, trifluoperazine
This medicine may also interact with the following medications:
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from light. Throw away any unused medicine after the expiration date.
They need to know if you have any of these conditions:
eating disorder, like anorexia or bulimia
heart disease or heart failure
heart rhythm problems
heart valve problems
history of low levels of calcium, potassium, or magnesium
stomach bleeding, blockage, or ulceration
an unusual or allergic reaction to cisapride, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
Visit your doctor or health care professional for regular checks on your progress. For this medicine to work properly it is important to make lifestyle changes. Eat smaller meals, elevate the head of your bed 6 to 8 inches, avoid high-fat foods, chocolate, alcohol, smoking, caffeine and carbonated drinks.
If you have any fainting spells or rapid or irregular heartbeat, stop taking this drug immediately. Contact your health care professional right away for evaluation.
Do not drink grapefruit juice while you are taking this medicine. Grapefruit juice could increase your risk of having serious side effects from this medicine.