PERPHENAZINE; AMITRIPTYLINE (per FEN a zeen; a mee TRIP ti leen) is used to treat depression that may be accompanied by anxiety or agitation. This medicine is also used to treat schizophrenia.
Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. You can take this medicine with or without food. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not stop taking this medicine suddenly except upon the advice of your doctor. Stopping this medicine too quickly may cause serious side effects or your condition may worsen.
A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
breast enlargement in both males and females
changes in vision
elevated mood, decreased need for sleep, racing thoughts, impulsive behavior
fast, irregular heartbeat
feeling faint or lightheaded, falls
feeling agitated, angry, or irritable
fever or chills, sore throat
hallucination, loss of contact with reality
suicidal thoughts or other mood changes
tingling, pain, or numbness in the feet or hands
trouble passing urine or change in the amount of urine
uncontrollable head, mouth, neck, arm, or leg movements
unusually weak or tired
yellowing of the eyes or skin
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
change in sex drive or performance
change in appetite or weight
Do not take this medicine with any of the following medications:
certain antibiotics like gatifloxacin, grepafloxacin, levofloxacin, moxifloxacin, sparfloxacin
certain heart medicines
MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
medicines for depression or psychotic disturbances
medicines for weight loss or ADHD
This medicine may also interact with the following medications:
atropine and related drugs like hyoscyamine, scopolamine, tolterodine and others
barbiturate medicines, like phenobarbital
local or general anesthetics
medicines for colds, flu and breathing difficulties, like pseudoephedrine
medicines for hay fever or allergies
prescription pain medications
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
Keep out of the reach of children.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Protect from light. Keep container tightly closed. Throw away any unused medicine after the expiration date.
They need to know if you have any of these conditions:
an alcohol problem
asthma, difficulty breathing
blood disorders or disease
difficulty passing urine, prostate trouble
heart disease or previous heart attack
over active thyroid
thoughts or plans of suicide or a previous suicide attempt or family history of suicide attempt
an unusual or allergic reaction to perphenazine, amitriptyline, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
Tell your doctor if your symptoms do not get better or if they get worse. Visit your doctor or health care professional for regular checks on your progress. Because it may take several weeks to see the full effects of this medicine, it is important to continue your treatment as prescribed by your doctor.
Patients and their families should watch out for new or worsening thoughts of suicide or depression. Also watch out for sudden changes in feelings such as feeling anxious, agitated, panicky, irritable, hostile, aggressive, impulsive, severely restless, overly excited and hyperactive, or not being able to sleep. If this happens, especially at the beginning of treatment or after a change in dose, call your health care professional.
You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.
Do not treat yourself for coughs, colds, or allergies without asking your doctor or health care professional for advice. Some ingredients can increase possible side effects.
Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.
This medicine may cause dry eyes and blurred vision. If you wear contact lenses you may feel some discomfort. Lubricating drops may help. See your eye doctor if the problem does not go away or is severe.
This medicine can cause constipation. Try to have a bowel movement at least every 2 to 3 days. If you do not have a bowel movement for 3 days, call your doctor or health care professional.
This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.
This medicine can reduce the response of your body to heat or cold. Dress warm in cold weather and stay hydrated in hot weather. If possible, avoid extreme temperatures like saunas, hot tubs, very hot or cold showers, or activities that can cause dehydration such as vigorous exercise.