ITRACONAZOLE (i tra KO na zole) is an antifungal medicine. It is used to treat certain kinds of fungal or yeast infections.
Take this medicine by mouth with a full glass of water. Follow the directions on the prescription label. Take this medicine with food. Avoid taking antacids, H2-blockers, or proton pump inhibitors within 2 hours of taking this medicine. It is best to separate these medicines by 2 hours. Take your medicine at regular intervals. Do not take your medicine more often than directed. Take all of your medicine as directed even if you think you are better. Do not skip doses or stop your medicine early.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
changes in hearing
pain, tingling, numbness in the hands or feet
signs and symptoms of heart failure like breathing problems; fast, irregular heartbeat; sudden weight gain; swelling of the ankles, feet; unusually weak or tired
signs and symptoms of liver injury like dark yellow or brown urine; general ill feeling or flu-like symptoms; light-colored stools; loss of appetite; right upper belly pain; yellowing of the eyes or skin
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
Do not take this medicine with any of the following medications:
certain medicines for blood pressure like felodipine, nisoldipine
certain medicines for cholesterol like cerivastatin, lovastatin, simvastatin, lomitapide
certain medicines for the heart like disopyramide, dofetilide, dronedarone, eplerenone, ivabradine, quinidine, ranolazine
colchicine (if you have liver or kidney problems)
ergot alkaloids like dihydroergotamine, ergonovine, ergotamine, methylergonovine
other medicines that prolong the QT interval (cause an abnormal heart rhythm)
red yeast rice
This medicine may also interact with the following medications:
antiviral medicines for HIV or AIDS
certain antibiotics like ciprofloxacin, clarithromycin, erythromycin
certain medicines for bladder problems like fesoterodine, solifenacin, tolterodine
certain medicines for cancer like axitinib, bortezomib, busulfan, dabrafenib, dasatinib, docetaxel, erlotinib, gefitinib, ibrutinib, imatinib, ixabepilone, lapatinib, nilotinib, ponatinib, sunitinib, trabectedin, trimetrexate, vinca alkaloids
certain medicines for depression, anxiety, or psychotic disturbances like aripiprazole, buspirone, diazepam, haloperidol, perospirone, quetiapine, risperidone
certain medicines for erectile dysfunction like vardenafil, sildenafil, tadalafil
certain medicines for pain like alfentanil, fentanyl, oxycodone, sufentanil
certain medicines for stomach problems like cimetidine, famotidine, omeprazole, lansoprazole
certain medicines that treat or prevent blood clots like warfarin, dabigatran, rivaroxaban
certain medicines for seizures like carbamazepine, phenytoin
certain medicines for tuberculosis like isoniazid, INH, rifabutin, rifampin, rifapentine
other medicines for fungal infections
steroid medicines like budesonide, ciclesonide, dexamethasone, fluticasone, methylprednisolone
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
Keep out of the reach of children.
Store at room temperature between 15 and 25 degrees C (59 and 77 degrees F). Protect from light and moisture. Throw away any unused medicine after the expiration date.
They need to know if you have any of these conditions:
history of irregular heartbeat
immune system problems
lung or breathing disease
an unusual or allergic reaction to itraconazole, or other antifungal medicines, foods, dyes or preservatives
pregnant or trying to get pregnant
Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse.
You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how the medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells.