VORICONAZOLE (vohr ih KON uh zohl) is an antifungal medicine. It is used to treat certain kinds of fungal or yeast infections.
This medicine is for infusion into a vein. It is usually given by a health care professional in a hospital or clinic setting.
If you get this medicine at home, you will be taught how to prepare and give this medicine. Use exactly as directed. Take your medicine at regular intervals. Do not take your medicine more often than directed.
It is important that you put your used needles and syringes in a special sharps container. Do not put them in a trash can. If you do not have a sharps container, call your pharmacist or healthcare provider to get one.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash or itching, hives, swelling of the lips, mouth, tongue, or throat
change in amount or color of urine
changes in vision
fast, irregular heartbeat
feeling faint or lightheaded, falls
fever, chills, or infection
pale colored stools
redness, blistering, peeling or loosening of the skin, including inside the mouth
unusual bleeding or bruising
yellowing of the eyes or skin
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
agitation, anxiety, or confusion
loss of appetite
pain at site where injected
Do not take this medicine with any of the following medications:
barbiturates like phenobarbital
certain antibiotics like rifabutin, rifampin
certain medicines for cholesterol like atorvastatin, lovastatin, simvastatin, lomitapide
certain medicines for irregular heart beat like dofetilide, dronedarone, quinidine
ergot alkaloids like dihydroergotamine, ergonovine, ergotamine, methylergonovine
other medicines that prolong the QT interval (cause an abnormal heart rhythm)
St. John's wort
This medicine may also interact with the following medications:
antiviral medicines for HIV or AIDS
birth control pills
certain medicines for blood pressure like amlodipine, nifedipine
certain medicines for cancer like vinblastine, vincristine
certain medicines for depression, anxiety, or psychotic disturbances like alprazolam, midazolam, triazolam
certain medicines for diabetes like glipizide, glyburide, tolbutamide
certain medicines for pain like alfentanil, fentanyl, methadone, oxycodone
certain medicines for stomach problems like omeprazole
certain medicines that treat or prevent blood clots like warfarin
medicines that lower your chance of fighting infection like cyclosporine, everolimus, tacrolimus
NSAIDS, medicines for pain and inflammation, like diclofenac, ibuprofen
other medicines for fungal infections
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
Keep out of the reach of children.
If you are using this medicine at home, you will be instructed on how to store this medicine. Do not use if the solution is discolored or if it has any solids in it. Throw away any unused medicine after the expiration date on the label.
They need to know if you have any of these conditions:
history of irregular heartbeat
an unusual or allergic reaction to voriconazole, other antifungal medicines, foods, dyes or preservatives
pregnant or trying to get pregnant
Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse. You will need blood work done while you are taking this medicine. Some fungal infections need many weeks or months of treatment to cure.
You may have changes in vision, including blurring and/or light sensitivity. Do not drive at night while taking this medicine. If you notice a change in vision avoid potentially hazardous tasks, such as driving or operating machinery. Avoid strong, direct sunlight during this therapy.
Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information.