AMPRENAVIR (am PREN a veer) is an antiretroviral drug. It is used with other medicines to treat HIV. This medicine is not a cure for HIV. This medicine can lower, but not fully prevent, the risk of spreading HIV to others.
NOTE: This drug is discontinued in the United States. Patients taking Amprenavir should contact their prescriber regarding discontinuation and alternative therapies.
Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Use a specially marked spoon or container to measure each dose. Ask your pharmacist if you do not have one. Household spoons are not accurate. You can take this medicine with or without food, but do not take it with a high fat meal. Take your medicine at regular intervals. Do not take your medicine more often than directed. For your anti-HIV therapy to work as well as possible, take each dose exactly as prescribed. Do not skip doses or stop your medicine even if you feel better. Skipping doses may make the HIV virus resistant to this medicine and other medicines. Do not stop taking except on your doctor's advice.
Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 4 years for selected conditions, precautions do apply.
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
nausea, vomiting, unusual stomach upset or pain
redness, blistering, peeling or loosening of the skin, including inside the mouth
trouble passing urine or change in the amount of urine
unusually fast heart rate
unusually weak or tired
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
changes in taste
increased hunger or thirst
tingling around the mouth
weight gain around waist, back, or thinning of face, arms, legs
Do not take this medicine with any of the following medications:
alcohol or any product that contains alcohol
female hormones, like estrogens or progestins and birth control pills, patches, rings, or injections
medicines for headaches like dihydroergotamine, ergonovine, ergotamine, methylergonovine
medicines for cholesterol like atorvastatin, cerivastatin, lovastatin, simvastatin
red yeast rice
ritonavir oral solution
St. John's wort
vitamin E supplements
This medicine may also interact with the following medications:
medicines for depression, anxiety, or psychotic disturbances
medicines for fungal infections like ketoconazole and itraconazole
medicines for blood pressure like amlodipine, diltiazem, verapamil
medicines for seizures
other medicines for HIV
If you miss a dose by more than 4 hours, wait and take the next dose at the regular time. But, if you miss a dose by less than 4 hours, take your missed dose right away. Then take your next dose at the regular time. Do not take double or extra doses.
Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.
They need to know if you have any of these conditions:
if you are of Asian, Eskimo, or Native American descent
if you frequently drink alcohol containing drinks
an unusual or allergic reaction to amprenavir, fosamprenavir, sulfa drugs, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
Visit your doctor or health care professional for regular check ups. Discuss any new symptoms with your doctor. You will need to have important blood work done while on this medicine.
HIV is spread to others through sexual or blood contact. Talk to your doctor about how to stop the spread of HIV.
Birth control pills, patches, rings, or injections may not work properly while you are taking this medicine. Talk to your doctor about using an extra method of birth control. Women who can still have children must use a reliable form of barrier contraception, like a condom or diaphragm.
This medicine contains large amounts of vitamin E. Do not take vitamin supplements that have vitamin E while you are taking this medicine.
This medicine may affect blood sugar levels. If you have diabetes, check with your doctor or health care professional before you change your diet or the dose of your diabetic medicine.