ESTRAMUSTINE (ES tra MUS teen) is a chemotherapy drug. It slows the growth of cancer cells. This medicine is used to treat prostate cancer.
Take this medicine by mouth with a glass of water. Take this medicine on an empty stomach, at least 1 hour before or 2 hours after food. Do not take with food. Do not take with milk or other calcium-rich food or drink. Follow the directions on the prescription label. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
signs of infection - fever or chills, cough, sore throat, pain or difficulty passing urine
signs of decreased platelets or bleeding - bruising, pinpoint red spots on the skin, black, tarry stools, blood in the urine
changes in vision
high blood pressure
pain, swelling, warmth in the leg
swelling of the ankles, feet, hands
trouble with balance, talking, walking
yellowing of the eyes or skin
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
breast enlargement in both males and females
change in sex drive or performance
loss of appetite
Do not take this medicine with any of the following medications:
This medicine may also interact with the following medications:
medicines to increase blood counts like filgrastim, pegfilgrastim, sargramostim
Talk to your doctor or health care professional before taking any of these medicines:
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
Keep out of the reach of children.
Store in the refrigerator between 2 and 8 degrees C (36 and 46 degrees F). Throw away any unused medicine after the expiration date.
They need to know if you have any of these conditions:
infection (especially a virus infection such as chickenpox, cold sores, or herpes)
an unusual or allergic reaction to estramustine, estrogens, other chemotherapy, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
Visit your doctor for checks on your progress. This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.
In some cases, you may be given additional medicines to help with side effects. Follow all directions for their use.
Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.
This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.
Be careful brushing and flossing your teeth or using a toothpick because you may get an infection or bleed more easily. If you have any dental work done, tell your dentist you are receiving this medicine.
Avoid taking products that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your doctor. These medicines may hide a fever.
Both men and women must use effective birth control methods to prevent pregnancy while taking this medicine. Do not become pregnant while taking this medicine. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Women, do not breast-feed an infant while taking this medicine.