EPLERENONE (e PLER en one) is used to treat high blood pressure. This medicine is also used to improve symptoms of heart failure.
Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. You may take this medicine with or without food. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on the advice of your doctor or health care professional.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
enlarged breasts or breast pain in males
fast or irregular heartbeat, palpitations
increased hair growth in females
irregular menstrual periods
unusually weak or tired
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
Do not take this medicine with any of the following medications:
certain antibiotics like chloramphenicol, clarithromycin, dalfopristin; quinupristin, and telithromycin
certain diuretics like amiloride, spironolactone, and triamterene
certain medicines for fungal infections like itraconazole, ketoconazole, posaconazole, and voriconazole
certain medicines for HIV or AIDS like atazanavir, cobicistat, darunavir, delavirdine, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir boosted with ritonavir, and tipranavir
grapefruit and grapefruit juice
potassium salts or supplements
This medicine may also interact with the following medications:
certain medicines for high blood pressure like enalapril, candesartan, lisinopril, and valsartan
NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.
They need to know if you have any of these conditions:
high blood level of potassium
if you are on a special diet, such as a low-salt diet and are using dietary salt substitutes
an unusual or allergic reaction to eplerenone, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
Visit your doctor or health care professional for regular checks on your progress. Check your blood pressure as directed. Ask your doctor or health care professional what your blood pressure should be and when you should contact him or her.
You may need to be on a special diet while taking this medicine. Ask your doctor. Also, ask how many glasses of fluid you need to drink each day. You must not get dehydrated.
You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.