HYDROCHLOROTHIAZIDE; SPIRONOLACTONE (hye droe klor oh THYE a zide; speer on oh LAK tone) is a combination of two types of diuretics. It helps you make more urine and lose excess water from your body. This medicine is used to treat high blood pressure and water retention from heart, kidney, or liver disease.
Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. You can take it with or without food. If it upsets your stomach, take it with food. Take your medicine at regular intervals. Remember that you will need to pass urine frequently after taking this medicine. Do not take your doses at a time of day that will cause you problems. Do not take at bedtime. Do not take your medicine more often than directed. Do not stop taking except on your doctor's advice.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions such as skin rash or itching, hives, swelling of the lips, mouth, tongue, or throat
black or tarry stools
changes in vision
fast, irregular heartbeat
feeling faint or dizzy
muscle pain, cramps
numbness, tingling in hands or feet
redness, blistering, peeling or loosening of the skin, including inside the mouth
trouble passing urine
unusually weak or tired
yellowing of the eyes or skin
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
breast enlargement in both males and females
change in sex drive or performance
dry mouth, increased thirst
irregular menstrual periods
stomach upset, nausea
Do not take this medicine with any of the following medications:
This medicine may also interact with the following medications:
certain medicines for blood pressure, heart disease like benazepril, lisinopril, losartan, valsartan
certain medicines that treat or prevent blood clots like heparin and enoxaparin
medicines that relax muscles for surgery
NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
steroid medicines like prednisone or cortisone
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
Keep out of the reach of children.
Store below 25 degrees C (77 degrees F). Throw away any unused medicine after the expiration date.
They need to know if you have any of these conditions:
immune system problems, like lupus
an unusual reaction to hydrochlorothiazide, spironolactone, sulfa drugs, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
Visit your doctor or health care professional for regular checks on your progress. Check your blood pressure as directed. Ask your doctor what your blood pressure should be, and when you should contact them. If you are diabetic, check your blood sugar as directed.
You must not get dehydrated. Ask your doctor or health care professional how much fluid you need to drink a day. Check with him or her if you get an attack of severe diarrhea, nausea and vomiting, or if you sweat a lot. The loss of too much body fluid can make it dangerous for you to take this medicine.
You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.
This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.