TOSITUMOMAB (TOE sih too MOE mab) is a chemotherapy drug. This medicine allows radiation to target specific kinds of white blood cells. It is used to treat non-Hodgkin's lymphoma.
This medicine is for infusion into a vein. It is administered in a hospital or clinic by a specially trained health care professional.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
low blood counts - this medicine may decrease the number of white blood cells, red blood cells and platelets. You may be at increased risk for infections and bleeding.
signs of infection - fever or chills, cough, sore throat, pain or difficulty passing urine
signs of decreased platelets or bleeding - bruising, pinpoint red spots on the skin, black, tarry stools, blood in the urine
signs of decreased red blood cells - unusually weak or tired, fainting spells, lightheadedness
feeling faint or lightheaded, falls
swelling of the ankles, feet, or hands
Side effects that usually do not require medical attention (report to your doctor or other health care professional if they continue or are bothersome):
loss of appetite
medicines that treat or prevent blood clots like warfarin, enoxaparin, and dalteparin
Talk to your doctor or health care professional before taking any of these over-the-counter medicines:
It is important not to miss a dose. Call your doctor or health care professional if you are unable to keep an appointment.
This drug is given in a hospital or clinic and will not be stored at home.
They need to know if you have any of these conditions:
low blood counts, like low white cell, platelet, or red cell counts
an unusual or allergic reaction to tositumomab, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
Report any side effects that you notice during your treatment right away, such as changes in your breathing, fever, chills, dizziness or lightheadedness. These effects are more common with the first dose.
Visit your prescriber or health care professional for checks on your progress. You will need to have regular blood work. Report any other side effects. The side effects can continue after you finish your treatment. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.
Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.
This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.
Be careful brushing and flossing your teeth or using a toothpick because you may get an infection or bleed more easily. If you have any dental work done, tell your dentist you are receiving this medicine.
Avoid taking products that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your doctor. These medicines may hide a fever.
Men and women must use effective birth control while taking this medicine and for 12 months after completing therapy. Do not become pregnant while taking this medicine. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine.
After taking this medicine you will have radioactivity in your body for a period of time, usually for a week or two following the treatment. Your doctor or other health care provider will give you instructions about how to prevent exposing others to this radioactivity. Follow all instructions carefully.