DIPHENHYDRAMINE; HYDROCODONE; PHENYLEPHRINE (dye fen HYE dra meen; hye droe KOE done; fen il EF rin) is a combination of an antihistamine, a cough suppressant, and a decongestant. It is used to treat the symptoms of the common cold, and of sinus and other upper respiratory tract infections. This medicine will help with a cough, and congestion in the nose or ears. This medicine will not treat an infection.
Take this medicine by mouth. Follow the directions on the prescription label. Shake well before using. Use a specially marked spoon or container to measure each dose. Ask your pharmacist if you do not have one. Household spoons are not accurate. Take your medicine at regular intervals. Do not take it more often than directed.
Talk to your pediatrician regarding the use of this medicine in children. This medicine is not approved for use in children.
Patients over 65 years old may have a stronger reaction and need a smaller dose.
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
changes in vision
chest pain, tightness
fast, irregular heartbeat
high blood pressure
numbness or tingling in the hands or feet
trouble passing urine or change in the amount of urine
unusually weak or tired
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
dry eyes, mouth
loss of appetite
Do not take this medicine with any of the following medications:
ergot alkaloids like dihydroergotamine, ergonovine, ergotamine, methylergonovine
MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
stimulant medicines like dextroamphetamine and others
This medicine may also interact with the following medications:
antihistamines for allergy, cough and cold
barbiturates like phenobarbital
certain medicines for sleep
medicines for depression, anxiety, or psychotic disturbances
medicines for urinary problems
narcotic medicines (opiates) for pain
some heart medicines like atenolol, propranolol
some medicines for sleep during surgery
St. John's Wort
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
Keep out of the reach of children. This medicine can be abused. Keep your medicine in a safe place to protect it from theft. Do not share this medicine with anyone. Selling or giving away this medicine is dangerous and against the law.
This medicine may cause accidental overdose and death if taken by other adults, children, or pets. Mix any unused medicine with a substance like cat littler or coffee grounds. Then throw the medicine away in a sealed container like a sealed bag or a coffee can with a lid. Do not use the medicine after the expiration date.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F).
They need to know if you have any of these conditions:
drug abuse or addiction
taken an MAOI like Carbex, Eldepryl, Marplan, Nardil, or Parnate in last 14 days
trouble passing urine
an unusual or allergic reaction to diphenhydramine, hydrocodone, phenylephrine, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
You may develop tolerance to this medicine if you take it for a long time. Tolerance means that you will get less cough relief with time. Tell your doctor or health care professional if your symptoms do not improve or if they get worse.
Do not suddenly stop taking your medicine because you may develop a severe reaction. Your body becomes used to the medicine. This does NOT mean you are addicted. Addiction is a behavior related to getting and using a drug for a non-medical reason. If your doctor wants you to stop the medicine, the dose will be slowly lowered over time to avoid any side effects.
This medicine may cause dry eyes and blurred vision. If you wear contact lenses you may feel some discomfort. Lubricating drops may help. See your eye doctor if the problem does not go away or is severe.
You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.
This medicine will cause constipation. Try to have a bowel movement at least every 2 to 3 days. If you do not have a bowel movement for 3 days, call your doctor or health care professional.