CERTOLIZUMAB (SER toe LIZ oo mab) is used to treat rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, non-radiographic axial spondyloarthritis, Crohn's disease, and plaque psoriasis.
This medicine is for injection under the skin. It is usually given by a health care professional in a hospital or clinic setting.
If you get this medicine at home, you will be taught how to prepare and give this medicine. Use exactly as directed. Take your medicine at regular intervals. Do not take your medicine more often than directed.
It is important that you put your used needles and syringes in a special sharps container. Do not put them in a trash can. If you do not have a sharps container, call your pharmacist or healthcare provider to get one.
A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
changes in vision
joint or muscle pain
numbness or tingling in any part of your body
signs and symptoms of infection like fever or chills; cough; sore throat; pain or trouble passing urine
signs and symptoms of liver injury like dark yellow or brown urine; general ill feeling or flu-like symptoms; light-colored stools; loss of appetite; nausea; right upper belly pain; unusually weak or tired; yellowing of the eyes or skin
swelling of the legs or ankles
swollen lymph nodes in the neck, underarm, or groin areas
unexplained weight loss
unusual bleeding or bruising
unusually weak or tired
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
irritation at site where injected
Do not take this medicine with any of the following medications:
biologic medicines such as abatacept, adalimumab, anakinra, etanercept, golimumab, infliximab, natalizumab, rituximab, secukinumab, tocilizumab, ustekinumab
It is important not to miss your dose. Call your doctor or health care professional if you are unable to keep an appointment.
If you give your medicine by injection under the skin: If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses. Call your doctor or health care professional if you are not sure how to handle a missed dose.
Keep out of the reach of children.
If you are using this medicine at home, keep the syringes in the refrigerator between 2 to 8 degrees C (36 to 46 degrees F). Do not freeze. Protect from light. Keep this medicine in the original container. Throw away any unused medicine after the expiration date on the label.
They need to know if you have any of these conditions:
hepatitis B or history of hepatitis B infection
immune system problems
infection or history of infections
low blood counts, like low white cell, platelet, or red cell counts
recently received or scheduled to receive a vaccine
tuberculosis, a positive skin test for tuberculosis or have recently been in close contact with someone who has tuberculosis
an unusual or allergic reaction to certolizumab, other medicines, latex, rubber, foods, dyes, or preservatives
pregnant or trying to get pregnant
Visit your doctor or health care professional for regular checks on your progress. Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse. Your condition will be monitored carefully while you are receiving this medicine.
You will be tested for tuberculosis (TB) before you start this medicine. If your doctor prescribes any medicine for TB, you should start taking the TB medicine before starting this medicine. Make sure to finish the full course of TB medicine.
Call your doctor or health care professional for advice if you get a fever, chills, sore throat, or other symptoms of an infection. Do not treat yourself. This medicine may decrease your body's ability to fight infection. Try to avoid being around people who are sick.
Talk to your doctor about your risk of cancer. You may be more at risk for certain types of cancers if you take this medicine.