AMITRIPTYLINE; CHLORDIAZEPOXIDE (a mee TRIP ti leen; klor dye az e POX ide) is an anti-depressant and a benzodiazepine. It is used to treat depression with anxiety.
Take this medicine by mouth with a drink of water. Follow the directions on the prescription label. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking this medicine suddenly except upon the advice of your doctor. Stopping this medicine too quickly may cause serious side effects or your condition may worsen.
A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
changes in vision
elevated mood, decreased need for sleep, racing thoughts, impulsive behavior
fast, irregular heartbeat
feeling faint or lightheaded, falls
feeling agitated, angry, or irritable
fever with increased sweating
hallucination, loss of contact with reality
suicidal thoughts or other mood changes
tingling, pain, or numbness in the feet or hands
trouble passing urine or change in the amount of urine
unusually weak or tired
yellowing of the eyes or skin
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
change in sex drive or performance
change in appetite or weight
Do not take this medicine with any of the following medications:
MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
narcotic medicines for cough
phenothiazines like mesoridazine and thioridazine
This medicine may also interact with the following medications:
antihistamines for allergy, cough and cold
antiviral medicines for HIV or AIDS
certain medicines for anxiety or sleep
certain medicines for bladder problems like oxybutynin, tolterodine
certain medicines for depression, like amitriptyline, fluoxetine, sertraline
certain medicines for Parkinson's disease like benztropine, trihexyphenidyl
certain medicines for seizures like carbamazepine, phenobarbital, phenytoin, primidone
certain medicines for stomach problems like dicyclomine, hyoscyamine
certain medicines for travel sickness like scopolamine
general anesthetics like halothane, isoflurane, methoxyflurane, propofol
local anesthetics like lidocaine, pramoxine, tetracaine
medicines that relax muscles for surgery
narcotic medicines for pain
other medicines that prolong the QT interval (cause an abnormal heart rhythm)
other phenothiazines like chlorpromazine and prochlorperazine
thyroid hormones such as levothyroxine
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
Keep out of the reach of children. This medicine can be abused. Keep your medicine in a safe place to protect it from theft. Do not share this medicine with anyone. Selling or giving away this medicine is dangerous and against the law.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees C). Protect from moisture. Throw away any unused medicine after the expiration date.
They need to know if you have any of these conditions:
bipolar disorder or schizophrenia
difficulty passing urine, prostate trouble
heart disease or previous heart attack
kidney or liver disease
over active thyroid
thoughts or plans of suicide, a previous suicide attempt, or family history of suicide attempt
an unusual or allergic reaction to amitriptyline; chlordiazepoxide, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
Tell your doctor if your symptoms do not get better or if they get worse.
Do not stop taking except on your doctor's advice. You may develop a severe reaction. Your doctor will tell you how much medicine to take.
You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.
If you are taking another medicine that also causes drowsiness, you may have more side effects. Give your health care provider a list of all medicines you use. Your doctor will tell you how much medicine to take. Do not take more medicine than directed. Call emergency for help if you have problems breathing or unusual sleepiness.
Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water will help. Contact your doctor if the problem does not go away or is severe.
This medicine may cause dry eyes and blurred vision. If you wear contact lenses you may feel some discomfort. Lubricating drops may help. See your eye doctor if the problem does not go away or is severe.
This medicine can cause constipation. Try to have a bowel movement at least every 2 to 3 days. If you do not have a bowel movement for 3 days, call your doctor or health care professional.
This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.