Intrinsic pathway coagulation factor profile, aPTT, partial thromboplastin time, PTT, blood coagulation tests
The aPTT is one of several blood coagulation tests. It measures how long it takes your blood to form a clot.
Normally, when one of your blood vessels is damaged, proteins in your blood called clotting factors come together in a certain order to form blood clots and quickly stop bleeding. The aPTT test can be used to look at how well those clotting factors are working. It's often used with other tests that monitor clotting factors.
Blood clots form in a specific series of steps called a pathway. This test mainly looks at how both the intrinsic clotting pathway and the common final pathway are working. The clotting factors involved are prekallikrein; high-molecular-weight kininogen; fibrinogen; and factors XII, XI, IX, VIII, II, V, and X.
You may need this test if your healthcare provider suspects that you have a problem with one or more clotting factors. If you have a bleeding disorder such as von Willebrand disease or another disease that prevents your blood from clotting, this test can help find out where the problem is.
This test is also used to monitor people who are getting heparin therapy. Heparin is a blood thinner used to prevent dangerous blood clots.
Depending on why you are having this test, you may have other blood tests that help measure how well your blood is clotting. Some of these tests might include:
Prothrombin time, or PT
Thrombin time, or TT
Activated whole blood clotting time, or ACT
Test results may vary depending on your age, gender, health history, the method used for the test, and other things. Your test results may not mean you have a problem. Ask your healthcare provider what your test results mean for you.
Test results are measured in seconds of time. Your results will show how long your blood took to clot, and will often compare them with results from a normal sample tested at the same time. A normal range is around 25 to 35 seconds, but test results will vary depending on equipment and methods used. Therefore, standard normal results will differ in each lab.
If your aPTT takes longer than usual, it may mean several things. Usually, other tests are done at the same time as the aPTT to better find out which factors are involved.
It's rare that your test will show an unusually short clotting time. If it does, it may be a sign of increased risk for blood clots (thrombosis), bleeding, or multiple miscarriages.
If this test is done because you are taking heparin to help prevent blood clots, your healthcare provider will usually want the aPTT to be about twice as long as what it would be normally.
The test is done with a blood sample. A needle is used to draw blood from a vein in your arm or hand.
Having a blood test with a needle carries some risks. These include bleeding, infection, bruising, and feeling lightheaded. When the needle pricks your arm or hand, you may feel a slight sting or pain. Afterward, the site may be sore.
Certain medicines, including heparin and warfarin (Coumadin), may affect the results of this test. If you are taking these medicines, check with your healthcare provider to find out when you should stop taking them before the test.
You don't need to prepare for this test. Be sure your healthcare provider knows about all medicines, herbs, vitamins, and supplements you are taking. This includes medicines that don't need a prescription and any illicit drugs you may use.