METHOXSALEN (me THOK suh luhn) is a skin coloring and light sensitizing agent. This medicine is combined with ultraviolet light or sunlight, in a therapy called PUVA. This therapy is used to treat vitiligo, a condition where skin color is missing.
This medicine is for external use on the skin only. Do not take by mouth. This medicine should only be applied by a physician to a well-defined area of skin before the area is exposed to ultraviolet A light.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
burning, blistering, or redness of the skin
increased sensitivity to the sun and skin irritation
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
generalized itching, dry skin
This medicine will make you sensitive to the sun. This effect may be increased by other medicines that also cause sensitivity to the sun such as:
certain staining dyes (examples: methylene blue, toluidine blue, rose bengal, or methyl orange)
medicines for infections including sulfa or tetracycline antibiotics
medicines for depression, anxiety, or psychotic disturbances
vitamin A and vitamin A-like medicines and creams
This medicine is only applied by a doctor or health care professional. For the treatment to be successful, light treatment must be done at the correct time after the lotion is applied.
This medicine will be applied in your doctor's office and will not be stored at home.
They need to know if you have any of these conditions:
absence of the lens in the eye
recent radiation therapy
skin photosensitivity problems
an unusual or allergic reaction to methoxsalen, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
Visit your doctor or health care professional for regular checks on your progress. You may see an improvement in your condition after a few weeks. The full effect can take 6 to 9 months of treatment. This medicine and PUVA can increase your risk of getting skin cancer. Show your doctor or health care professional any unusual sores or blemishes that develop. If your skin gets very dry, ask your doctor or health care professional before you use any skin products.
This medicine can increase sensitivity of the skin to sun or UV light. This could lead to a serious burn. Keep out of the sun for at least 24 hours before and 48 hours after PUVA. Keep out of the sun for 12 to 48 hours after application of this medicine. If you must be outside, wear protective clothing and use a sunscreen (at least SPF 15). Do not apply sunscreen to areas of psoriasis until after light therapy. Do not use sun lamps, sun tanning beds or booths. Certain foods can increase your sensitivity to sunlight while using this medicine. Avoid eating limes, figs, parsley, parsnips, mustard, carrots, and celery while using this medicine.
You can get permanent premature aging of the skin if you use this medicine for a long time. This effect is similar to the result of too much sunbathing.
Recent treatment with radiation therapy or cancer medicines increases the chance of developing side effects from combined light treatment and this medicine.